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10:19 · Aug 02, 2025

This Is What High Insulin Does To Your Body (Worse Than You Think)

Dr. Anthony Chaffee explains how insulin levels control over 100 bodily processes and reveals why fasting benefits may simply come from avoiding carbohydrates rather than the act of not eating itself. When insulin stays low (ideally under 9, but one patient had a dangerous level of 72), the body can naturally produce ketones, perform autophagy, and access fat stores for energy - processes that high insulin from carbohydrate consumption completely shuts down.

The discussion covers why ketogenic diets are actually the most extensively studied dietary approach in medical research, with thousands of randomized controlled trials showing benefits. Dr. Anthony Chaffee addresses common concerns about nutrient deficiencies on keto, explaining that no essential carbohydrates exist and that entire civilizations have thrived without them, while highlighting the unreliable nature of epidemiological studies that claim plant-based diets are superior.

Key Takeaways

  • Keep fasting insulin levels below 9 to allow proper autophagy, ketone production, and fat burning - levels above this (like one patient's dangerous 72) suppress these critical metabolic processes
  • Fasting benefits primarily come from avoiding carbohydrates that spike insulin, not from the absence of food itself - ketogenic eating provides the same metabolic state while allowing you to eat
  • No essential carbohydrates exist in human nutrition - your body produces all the glucose it needs through gluconeogenesis while entire Arctic populations survived generations without any plant foods
  • Ketogenic diets have more rigorous scientific backing than any other dietary approach, with thousands of randomized controlled trials versus plant-based studies that rely on unreliable self-reported surveys with healthy user bias
  • Insulin's Role in Metabolism and Fasting vs Ketogenic Benefits
  • Ketogenic Diet Safety and Essential Carbohydrate Myth
  • Vegetarian Keto Problems and Processed Foods vs Whole Foods
  • Nutritional Epidemiology Problems and Study Quality Issues

This is an auto-generated transcript from YouTube and may contain errors or inaccuracies.

Insulin affects over 100 different processes in your body like autophagy, >> right? So, it's not the not eating that's doing it. It's just that high insulin suppresses autophagy >> and it suppresses all these other functions in your body and it suppresses the formation of ketones. It for basically you can think of it as forcing energy into cells. It doesn't allow it to come out of cells. So, when your insulin level is up, you can't start using your fat as energy. So, that's really all it is. It's just going to the the classic metabolic state that we're supposed to be in. Our insulin can be nice and low. If we're not taking in carbohydrates, we're not taking in sugar. Then we make carbohydrates, we make blood sugar, we make glycogen, we make ketones, but they're at exacting levels. They're exactly where your body needs them, okay? And you produce them on the fly, okay, >> for for your body's demands. And then your insulin is nice and low. It's affecting your because if you if you have just normal blood sugar and your insulin's at a five, >> right? it's affecting all these other things, all these hundred other things at a five. But then you eat a sandwich or have a piece of pie and it's up at 35, right? Well, now your insulin is at a 35 affecting everything else at a 35. And I had a patient that came in two weeks ago to my office and he had a fasting insulin of 72. It never should be above nine, >> right? >> So it was and that's fasting, right? So what if this guy had a piece of cake? What in God's name was that going to do? So, >> so the effects that you're seeing are similar to when somebody comes off a just a shitty diet. If you go to vegetarian, you get all of these benefits because it's cut out everything, >> right? Um same thing as going to meat, you cut out all the processed stuff. So, if you're comparing keto to carbs, >> the fact that if you sorry, fasting to keto, >> the fact that you're fasting just mirrors what we do normally because we're not having that carb in our diet. >> That's it. >> So, people have So, your is this is this your theory that we have got um the fasting wrong because it's just matching what we would naturally do, but people have seen that happens when we're fasting and not taken into account. And so fasting and ketogenic are like mirroring. It's similar. >> Yeah, that's it. So it's it's um fasting is the the main benefits of fasting is you're just not eating the wrong things. You're just not eating >> because you're cutting out the car. You're cutting everything out. Whereas if keto, you're just cutting out carbs >> which are increasing our insulin. >> I'm interested as well. >> That's way easier to do is to eat keto than to not eat. >> Yeah. You know, >> well, and and there's studies that say that, you know, right? Because there there there are just tons and tons of studies on on fasting that show all these benefits and populationwide things. You know, people that fast for religious reasons, they tend to have lower rates of chronic disease and heart disease. They live longer. All these different sorts of benefits when you have specific end points like like in diabetes, they showed that you could reverse diabetes type one and type two in rats by fasting for at least four days a month. And they said, "Okay, well fasting is really difficult. What about a diet that mimics fasting? You can still eat, but you're still in that metabolic state." So this fasting mimicking diet. So FMD. So this is what it's called because ketogenic diet is a sort of a four-letter word in a lot of academic circles. So they they hide it by saying, "Wow, we want to mimic fasting." So it's not it's not a ketogenic diet. Oh, no. It's a it's a fasting mimicking diet, right? >> And it has exactly the same benefits as >> what are what are the dangers of a keto diet? cuz like if I was to eat keto from now for the next 6 months, is there any danger that I have >> of things that I'm going to be missing out from eating what I would normally eat? Cuz that's what scares me. I've got this app where it's a keto cycle app. >> Yeah. >> Um I quite like it cuz it gives you >> My biggest issue is walking into a supermarket, I don't know what the [ __ ] what to buy. And this gives you a list of all the ingredients >> and then you've got the recipes which is pretty sweet. And just like little snacks like having smoked salmon with cucumber and some um cream cheese. cuz I was like [ __ ] this is hell killer and it's >> allegedly good allegedly. >> So basically, yeah, back back to that original question, what is the key >> dangers? Yeah. >> Yeah. What is what's in it? And then what Yeah. What are the dangers? >> Yeah. Well, so so that's a that's a good point because a ketogenic diet just means don't eat carbs. >> Okay. >> Which is sugars, which is anything. >> Carbohydrates. So everything tasty. So, you're not you're not you're not missing out on anything because there's no such thing as an essential carbohydrate. That's a wellestablished fact in in in medicine and biology. There's no such thing as a as a an essential carbohydrate. You make carbohydrates. >> That's interesting. The making carbohydrates, but we'll come back to that. >> Being Italian would do that. >> Yeah. Yeah. Yeah. >> Yeah. And um yeah, just little just some bread rollers ravioli. >> Yeah. And um so yeah, so that's it. It's just there's no such thing as an essential carbohydrate. There's no carbohydrates that you need. There entire civilizations that go generation after generation after generation. Don't eat any carbohydrates. What carbohydrates were available when people were crossing the land bridge from Asia to North America during an ice age in the Arctic Circle. Nothing. There's nothing there except meat, right? So if we weren't able to survive on that without that, that it's just impossible. Like we would be dead. They wouldn't have been able to cross it. So there's no such thing as an essential carbohydrate. you make all the carbohydrates you need and in fact you're better able to do it if you just leave your body alone and get on with it because your insulin's nice and low and now you can mobilize it. So there are different kinds of ketogenic diet. Ketogenic diet just means don't eat carbs. And so depending on how you structure that, yeah, you could be missing something, right? You could do a vegetarian version of a ketogenic diet. You'd have to get a lot of plant fats and oils and I don't drink, you know, canola oil or something like that. Would it be something like um avocados and stuff? Would that be considered or >> uh Yeah. Yeah. Yeah. She could do like avocados. Wouldn't be much carbs in there, you know. So, if you wanted to do sort of a vegetarian keto diet, you could it would be difficult more difficult to structure that to get enough energy because you're replacing carbohydrates. You have to replace that u with proteins and fats. And so, that's a bit more difficult. Hey guys, just want to take a second to thank our sponsor, Carnivore Bar. I don't promote many products because honestly all you need to be healthy is to just eat meat. For those times that you're out hiking, road tripping, or stuck at work and you want nutritious snack that is just meat, fat, and salt if you want it, the Carnivore Bar is a great option. So, I like this product not because it's just pure meat, but also because I want the carnivore market to thrive as well. And the more we support meatonly products, the more meatonly products there will be available in the mainstream. So, if this sounds like something you'd like to get behind, check it out using my discount code Anthony to get 10% off, which also applies to subscriptions, giving you 25% off total. All right, thanks, guys. >> And would it be generally not great for your health cuz it's processed and it's Yeah. vegetable seed oils and stuff like that. >> I Yeah, I mean, I I wouldn't, you know, I don't think it's I don't think it's great. >> Clearly, you wouldn't. >> But um but if you think about it, it's going to be much more difficult. you you you can easily fall into a trap of getting a bunch of processed crap >> and seed oils and all that sort of stuff >> and and you're going to be very nutrient deficient, right? You're going to have to supplement heavily to get this and you're getting all the plant toxins, all that sort of stuff. But all that aside, it's just going to be very difficult >> to get the amount of energy and nutrients that you need without heavy supplementation. But um these studies and there are literally thousands of studies on ketogenic diets. It's the most robustly studied diet in existence. No one has studied any diet more closely and at a higher level with randomized control trials, interventional trials in animals and humans than the ketogenic diet. All these saying, oh the plant-based diet, it's most no it's survey studies saying this. Oh, what did you eat last year? I'm like, you know, and they they say they eat more plants and things like that. There's healthy user bias because people that that are doing one thing that they think are healthy, they're going to do other things they think are healthy, like they're not going to smoke, they're not going to have as much sugar, they're they're not going to eat as many calories and all these sorts of things. And you see this all throughout those sorts of studies. >> Um that people that eat more vegetables um first of all, they're eating more vegetables compared to a processed food diet. And the processed food diet is largely plant-based anyway. So you're doing just doing that whole thing. But also, you know, you you have all these other sorts of healthy user bias sort of things as well. >> Um, so but those are survey studies. Those are crap, right? There's ep, you know, nutritional epidemiology is is garbage. You could do it well, but they tend to not they tend to just do it in as slap dash of a way as possible. like the nurses study is something that's quoted all over the place because of Walter Willlet from Harvard and you know he's very very influential guy but uh he works with the Seventh Day Adventist and they they try to push this plant-based ideology and so the nurses study they have all these nurses tens of thousands of nurses around the US I know some of them and uh they send them a survey every year and say oh what did you eat last year like >> why why nurses >> oh it's just yeah it's just that that's the population they chose right um and uh you know and so they got they got all these nurses around around the US and they just say, "Hey, what um you know, what did you eat last year?" It's not, "Hey, can you track your meals for the next year?" >> Yeah. >> It's, "Hey, try to remember all the meals you had last year." >> And they they get embarrassed and they want to seem like they're doing the right thing. So, they go, "Oh, lots of veggies." >> Yeah. Well, and that's it. And so, the ones that are saying, you know, more veggies or they seem to be healthier than the other ones, but it's it's it's very inaccurate, you know. I mean, they're saying, first of all, the average male nurse uh was eating like 200 two or 300 less calories than the average female nurse. like really? They were all eating like 1,200 to,400 calories. I'm like, I've seen >> most nurses take down about 1,400 calories of chocolate per shift. So, like >> I don't know about that. But so, it's it's very inaccurate. And uh that's that's the level of of of uh data for the plant-based studies, right? >> Is that called uh you I think you just said it before. Was it epidemiology? When they just report, self-report? >> It's Yeah. You're just looking at sort of big broad >> Yeah. sort of uh you know thing survey or something. Yeah, exactly. You're not it's not an interventional trial. It's not an experiment. It's not experimental data. You're just sort sort of observation. >> Oh, honey, that's an animal product, right? Well, it's actually, you know, bee vomit and they're just vomiting up concentrated nectar, okay, which comes from a plant. So, if you want to get technical, it goes back and uh, you know, it's not it's not exactly an animal. Um, but it's also sugar, okay? So there's more fructose.
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