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17:44 · Jun 03, 2025

Millions Misdiagnosed Because of THIS Medical Standard... | Dr. Sarah

Dr. Anthony Chaffee exposes how medical reference ranges based on population averages rather than optimal health levels are masking widespread nutritional deficiencies and perpetuating chronic disease. He explains how the current system uses deficient populations to establish "normal" ranges, meaning patients testing within these ranges may still suffer from serious nutrient deficiencies that cause neurological damage, autoimmune conditions, and other health problems.

The discussion reveals how vitamin B12 deficiency is particularly dangerous, with Oxford University research showing brain shrinkage of over 5% in people with levels under 308 pmol/L, yet many labs consider levels as low as 150 pmol/L "normal." Dr. Anthony Chaffee argues that autoimmune diseases like Hashimoto's and celiac may actually be the body's appropriate response to harmful substances rather than true autoimmune conditions, as removing triggers like gluten allows gut healing within 4-6 weeks despite persistent antibodies.

Key Takeaways

  • Medical reference ranges based on population averages hide serious deficiencies - B12 levels under 308 pmol/L cause measurable brain shrinkage, yet many labs consider 150 pmol/L normal
  • Different laboratories use vastly different reference ranges for the same nutrients, with B12 "normal" ranges varying from 550 to 1000 pmol/L depending on the lab
  • Autoimmune conditions may resolve by removing dietary triggers rather than requiring lifelong medication - celiac patients see complete gut healing in 4-6 weeks after eliminating gluten
  • Western diets cause systematic nutrient deficiencies because 75-80% of calories come from plants that lack essential nutrients like B12 and contain anti-nutrients that block absorption
  • Medical Reference Ranges vs Optimal Nutrient Levels
  • Hashimoto's Thyroid Disease and Autoimmune Misdiagnosis
  • Vitamin B12 Deficiency and Brain Damage from Low Reference Ranges
  • Medical School Training and Lab Reference Range Problems

This is an auto-generated transcript from YouTube and may contain errors or inaccuracies.

[Music] If we just change that one thing, just like used optimal reference ranges as opposed to the average reference ranges, that would that would just revolutionize medicine all on its own. I mean, just right there, it would be it would be a massive difference. Um, because doctors would have something to go on, you know? I mean, we have all these, you know, known symptoms of of vitamin B12, of low vitamin B12 or these other sorts of things being a bit off, and we know how important zinc and magnesium are and all these sorts of things. But then if you're using reference ranges based on an average, and the average person has low B12 because 75 80% of calories in a western diet are plant-based. You know, it's mostly processed plants, but they're still plants and plants don't have B12. And so, you know, especially people that that have some meat in their diet, oh, I'm getting plenty of B12. You're not actually you're not getting nearly enough. And you're also blocking out the absorption because of the anti-nutrients in plants. And so, that average is skewed. And so, you know, you're looking at an average, but it's actually deficient. And so, you know, we're um we're unaware of that. And so if doctors were aware of that and actually saw just how low everyone was, you know, that they'd actually have somewhere a direction to go in, like your vitamin D is low as hell, your um your zinc is low as hell, your potassium is low as hell, your B12 is low as hell, like all these things are low as hell, or your hormones are all off because again, it's an average. You know, even even um Hashimoto's the antibodies, they they do that on averages as well. They say it's like, well, as long as it's as long as the antibodies are below this level, then it's fine. It's like that doesn't mean you don't have Hashimoto's. It's like you have Hashimoto's. You have antibodies for this condition. That's the definition of an autoimmune disease. You have those, you know, termed auto antibodies. I don't think they are an auto antibod. I think your body's attacking something else that's attacking your thyroid, right? Like celiac, you know, gluten attacks your interasytes and then your body mounts in response against that damages the the villi and the microvilli. Gluten does that all on its own and um your body's doing exactly what it's supposed to do, which is protect your body from that insult. But then when you remove the gluten um the the gut heals in four to six weeks completely and even though those antibodies stay elevated for over 3 years. So now you have active floating you know circulating antibodies but no damage. So obviously that's not an autoimmune disease that's that's something else. And so I think it's probably the same with other autoimmune issues, you know, like MS and and um and Hashimoto's etc. because it's um you know you take these things away um even before you correct the vitamin D that the problem goes away and and people's symptoms start going down and start improving. You can see that very quickly with the gut autoimmune issues like Crohn's disease and ulcerative colitis because the gut has such high turnover. or it heals much more quickly, but those antibodies are up and um uh and yet the gut's healing and their and their issues are going away within within weeks. And um so yeah, so you know, it's um yeah, I think it's I think it's quite a bit different, but you know, when you're diagnosing these things and like I think that's a really good way of putting it that like western medicine is really good for the diagnostics, but not necessarily the treatment. And certainly acute care, you know, like that that we've got nailed down, but um you know, the treatment of of the chronic conditions, not so much, but you know, you have this and you'll have that range. And it says, well, below this much your TPO antibodies or TG antibodies. Well, below that, that's fine. You don't have Hashimoto's. Like, no, you just don't have a flare up of Hashimoto's, but you have the antibodies. That's the definition of of that condition, you know, and um and like you know, if you go on a carnivore diet and your antibodies come down to lower than that level, which I see happen all the time, that doesn't mean you don't have Hashimoto's anymore because as soon as you go off that and you eat something up, boom, they just go right up. And um so yeah, it's very strange like these these reference ranges. But if if we had more, you know, more normal reference ranges that actually denoted optimal health, then this would be very different. 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All right, thanks guys. it's in the what what is hard to I don't think it's hard to understand once you start to think more about human nature but if you look at the science those things are in the literature regarding what which levels make sense and then I see a lot of the research is not consistent with what the reference ranges are and yeah exactly and you know I mean yeah you're right I mean this isn't This isn't like something that someone made you know made up. You know it was it was based on um you know very uh you know good data much better data you know like the the reference ranges that are used typically just the average you know first few thousand people that come in that year that is the reference range. Um some do better than others. We'll say okay well we'll go from from 20 to 39. I saw this recently actually 20 to 39 and normal BMI right there. that's already an improvement. At least you're thinking like maybe maybe there's some difference here in this population. You're not just going to put every any average Joe. Um but okay, why but there there, you know, quite a lot of people that have metabolic syndrome and diabetes and have normal BMI or cancer, you know, and all sorts of different things. It can skew these numbers in all sorts of different directions. And um and it doesn't matter what your BMI is. you can be B12 deficient at any weight, you know, and so you know, it's not um uh and you know, and if you're yeah, you know, malnourished, you're even more likely to be low on B12 and be skinny as well. So, you you have to you so there have been studies done um like in Germany and elsewhere where they they looked at people in their 20s, average age 25, normal BMI, but also no diagnosed medical condition. So even then, you don't know if they're B12 deficient or whatever. But at least it's another step. It's like they're just not sick. They don't have diabetes. They don't have cancer. They don't have autoimmunity. This is just a nominally healthy population. And um and that already is a massively different um set of reference ranges. And uh and then for like specific nutrients like B12 or vitamin D or something. I mean there's people that have been studying this for decades and um and they've come up and say hey look this is what we find is uh is the best range for optimal health and when you have you know half of the reference range in or more than half of the reference range for B12 in most countries um aligning with levels that in in various uh studies have shown is actually causing serious neurological dysfunction. But you can get, you know, MS is a is a deminating disease. If your B12 is low enough, you can get demolination just from the low levels of MS. And so, you know, and you can actually get shrink, you know, narrow thinning of your spinal cord and the gray matter or white matter starts to shrink um and your brain shrinks. So Oxford University showed that under 308 peak moles per liter of B12 that people's brains were shrinking by over 5% after in 5 years and um but the the deficiency level was under 150. So this is double that deficiency range and yet their brain shrinking and above I think it was below like 500 people's brains were still shrinking by 2.5%. So a lot of the reference ranges go up to like in in the UK some I've seen it at go up to 550 you know or 600 650 below 500 is such a profound deficiency that the brain you're getting brain damage and the brain is shrinking in volume as you can measure on MRI. So, how could we possibly call that a normal or acceptable B12 range? But we are because of that average. And and so now so many people are getting neurological damage directly just from the B12 and however many other sorts of things that that are out of range. But especially when you're when you're dealing with something like MS, you you can't regrow you can't reminonate your your nerves unless you have better B12 levels. you'll get demolination. If anything, it'll keep going back down the other way. So, I mean, just that I mean, just changing those reference ranges to use actual optimal reference ranges. And so, like every lab was, you know, in you know, in conjunction with others, then um you know, right there you just dodger just have a lot more to go on instead of having to learn those reference ranges ourselves and then say, "Okay, yeah, these are all wrong. This is the ones you want to use." you know, because that can be quite confusing to patients as well when you're saying, "Yeah, all these things are wrong." And most of them get it, but um it's still be nice if it was just like barn door. Yeah, this is low, this is high, this is low. Hey everyone, really happy to announce a new sponsor for the show for everybody down in Australia. Stockman Steaks, who are delivering highquality grass-fed and finished, pasture-raised beef and other meats, flash frozen, and vacuum sealed to your door. Something I've been enjoying a lot of myself recently as well. They also have a great range of specialty items such as highfat keto mints and carnivore beef and organs mints with liver, kidneys, and beef art as well. So, use code chaffy today for a free order of beef mints or another specialty gift along with your order at stockmanstakess.com.au and I'll see you over there. Thanks, guys. Yeah, because then what are people supposed to trust? And I think a lot of people do trust their doctors, you know, and I don't doctor's fault, per se. I think they're educated in a system that is designed that way. Um, and and probably intentionally so. Um, if you at what's happened with systematic nutrient deficiency, you get a lot of the illnesses too that we have today. Um, and it's kind of like the perfect crime, right? because you can't point to a villain in the story since know you were in the reference range. So, um if you know the reference ranges are inconsistent with a lot of the science, uh then you know you can I think leaving I think having reference ranges that are deficient I don't think that that's an accident. Um but I don't think that it's a physician's fault. I think it's just they are kind of getting passed through the system um and they're perpetuating information that they've learned uh in medical school and you know I I question that information that they're Yeah. Well, and and it is I mean they you know this wasn't this wasn't directly taught to my class anyway of just like oh by the way different labs use different ranges because it's all on average that that came about just randomly. We were at at the after class we was talking to one of the the professors that had like an interesting talk. I remember there's this group of us sort of talking to him afterwards asking questions and and said that [Music] um said that um you know he he was talking about different reference ranges and it was just like oh well this is this and this and I was like and there's two numbers and there's a discrepancy. I was like well hold on why why are those different why are those reference ranges different? Why are they saying that's normal and that one's not normal? And saying, oh, well, they because it came from different labs. And I was like, why why would that matter? Like why why would that change what what what levels are normal? And they said, oh well, they just use averages. That's just how they do it, you know. So, um, you know, I was just like it was just like, well, why? He's like, oh yeah, they all just use averages. So, the average that comes in, so the different people that will come into different labs all just be a different average. It was all just very very matter of fact. and and um it's like yeah that's normal that's just what they do but why why would that because you know it was like one of them was out of range and one was in range okay well then which one is it you know it's the same number so why would that be why would that be too low or too high you know and and um one of my patients was um got one of her other doctors like um was saying that something was out of range and she was like well no actually these are these optim more ranges and and he just like went out like told her off. He was one of those guys that was just like, you know, you just you just listen to everything that I say and no talkback sort of sort of doctors. They were horrible bedside manner sort of guys and like um and she was just like, well, why why would that I'm going to different labs like it's going up and down and things like that and you know it's like well you know depending on the on the region you're at you that that matters your your environment matters for your blood test. like no it doesn't like like why would like why would it matter and also we're talking about in the same city the same town there's different reference ranges in pathology labs that are directly next to each other so the same environment you know very different uh reference ranges and and acceptable ranges and um you know if your B12 is you know uh 250 so you're in that dangerous range out of Oxford and um you And then, you know, but at this lab it says no, that's fine. That doesn't mean that it's fine. You're in that bad range. And if your if your B12 is and you know, for instance, like there was there's some reference there's some labs in the UK um that I that I for patients that I consulted with um and um they're the reference range went up to 550. So in Perth, one of the labs go up to 650 and one goes to 750 and one goes to a,000. Okay. Well, which one is it? You know, you you know, if you're if you're 900, you know, you'll be normal at one lab and and and uh and be toxic in two others. And then if you you know, if you're 600, so you're normal in all of those labs, but you fly to the UK the same day and you're still 600, now you're toxic. And it's just like just being in England makes you B12 toxic. It's like it's I mean, you know, if if the guy can think he wasn't that day, you know, but um you thinking that oh, your environment matter, your environment change. No, it doesn't. That's stupid. And like it's just so dumb. But uh but you know, um yeah, so that that's that's very important. And um yeah, it would just change everything. It would absolutely change everything if we just actually used optimal reference ranges. I No, I would agree. I don't I just don't think it's designed Um, I'm I like I said, I don't think it's by accident that those are the ranges that physicians are given to talk to their patients about. So, I think it's it helps maintain illness basically. Well, yeah, it would, wouldn't it? Yeah. I mean, by design or not, it it does. You know, if everyone's deficient in their nutrients and all these sorts of things, then, you know, you're not able out there. It would be different if it was difficult to find, but it's all in there in the research in terms of that's sort of why I believe that about okay well the all the information to help you is available but it's not actually being used um or taught. Um how is that not deliberate? um if if what your goal is to is to help people um it's it looks like negligence to me or you know um so like I said I you I tend to use um you know appreciate the medical system in the United States for diagnostics. Yeah, it's not going to hurt you could very well help and uh that's the whole point. So thank you very much uh for that and any if you have any final final thoughts you know please do share. Um but uh I I know that you don't like sharing social media and things like that so I I won't ask that. Oh I don't actually have yeah I don't have social media. I have now I
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